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This type of cell death is characterized by the buildup of iron and lipid peroxides within the cell ( Numerous researchers have described the signaling cascades involved in ferroptosis (Figure 1), emphasizing various NADPH-dependent enzymes, such as G6PD, glutathione peroxidases, and phospholipid hydroperoxide glutathione peroxidase (GPx4) ( FIGURE 1 3 Ferroptosis and PF In the context of pulmonary fibrosis, accumulating evidence supports the concept that ferroptosis plays a critical role in driving the fibrotic process ( Several molecular mechanisms have been implicated in the relationship between ferroptosis and pulmonary fibrosis

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Lloyd, S