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The standard protocol includes: 1200 mg to 2400 mg per session, depending on the individuals body weight and skin tone Sessions are typically administered once or twice per week It can take 10-20 sessions of a complete whitening treatment, and then it is necessary to go every month

For survival analysis, AKP tumour-bearing mice were generated as above, and 26 days after induction, they were treated with 150 mg kg 1 5FU (i.p.) 250 mg kg 1 metformin (o.g.) three times weekly

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