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We reasoned that KD efficiency can vary between cell types and classes depending on the baseline expression level of the target gene, and that KD effects may be difficult to detect in cell types with low baseline expression

10.1016/j.jpain.2024.104588 71 LouisP.YoungP.HoltropG.FlintH

Maternal serum alpha-fetoprotein (MSAFP) at 15-18 weeks (1) If elevated, then the patient should be evaluated with a targeted ultrasound for fetal anomalies, including neural tube defects and abdominal wall defects (gastroschisis and omphalocele) (2) If low, then the patient should be offered a genetic amniocentesis to evaluate the fetus for trisomy 21 (Down's syndrome) g

PLoS Pathog 7 , e1001271 (2011)