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In animal models, glial cells such as astrocytes and NG2 oligodendrocyte precursor cells can be directly converted into functional neurons in vivo via ectopic expression of neurogenic transcription factors like NeuroD1 and Ascl1

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Nevertheless, over the last twenty years there has been an increasing number of clinical studies evaluating nose-to-brain delivery as a novel option for the treatment of neurodegenerative and neurological diseases

For short trips, reconstituted peptide can be kept at room temperature for up to 72 hours without significant degradation, though refrigeration is always preferred