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ERK5 is a known weak client of Hsp90, and prolonged occupancy of the N-terminal ATP-binding pocket by potent inhibitors such as ganetespib or by HLX itself destabilizes a subset of Hsp90 clients, including ERK5 [48,49,50]

Accutane is a highly effective treatment for the most severe forms of acne, including cystic acne and nodular acne, that can be used to eliminate breakouts when all other forms of treatment have been ineffective

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

the time intervals for the study were as follows: 0.5hr, lhr, 2hr, 4hr, 6hr, 8hr, lOhr, l2hr, 24hr after application of a patch