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However, the molecular events that promote these alterations are incompletely understood (6)

However, the clinical relevance of its effects is currently unclear, given the limitations of the studies identified, including the heterogeneity of studies, the number of studies with insufficient power, and other methodologic considerations [100]

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In the present review, NSCLC metabolism was discussed with a focus on the potential of metformin-based targeting of NSCLC metabolism and the associated mechanisms, and the available preclinical and clinical evidence was assessed