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Macrocyclic lactone Rapamycin, a macrocyclic lactone isolated from Streptomyces hygroscopicus , is known for its immunosuppressive and antimicrobial properties due to its ability to inhibit the mTOR pathway, thereby promoting autophagy [63]

doi: 10.3390/ijms241411680 117 LinJ.ZhouD.SteitzT

meningitidis resides as a colonizer in the human nasopharynx, which is its unique environmental niche (Coureuil et al., 2019)

The mitochondrial DNA encodes for all the RNA involved in protein synthesis in the matrix but also for 13 proteins that are subunits of the ETC complexes: seven subunits in Complex I, one in Complex III, three in Complex IV, and one in the ATP synthase (sometimes called complex V)