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S1), which may explain the very low response reported in an earlier study [14]

In the PRECISE-IVUS (Plaque Regression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by Intravascular Ultrasound) trial, patients randomized to receive combination therapy of atorvastatin plus ezetimibe experienced a greater reduction in percent plaque volume at 9-12 month follow-up (-5.2%, n=100) than those who received monotherapy (atorvastatin alone

The applicant provided two analyses to demonstrate that the technology meets the cost criterion, the first using 100 percent of all identified cases, and the second using 75 percent of all identified cases

Phytomedicine 2000;7:273-82