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in addition, it appears that GLP-1 can directly reduce hepatic lipogenesis and expression of lipogenesis-related genes through the cAMP/AMPK pathway [44]

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Increased levels of GH and IGF1 in the circulation stimulate the release of somatostatin, which interacts with somatostatin receptors and negatively regulates GH secretion from the anterior pituitary

doi: 10.1186/s12974-016-0644-1 109 RighiMMoriLDe LiberoGSironiMBiondiAMantovaniAet al