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therefore, molecules that modulate kinase functions are expected to be promising new drugs

One study report that Factor V Leiden is present in 11% of G6PD-deficient patients, a significantly higher incidence than the 2.4% reported in the normal population of Dalmatia [47]

The decrease in volume of distribution is due to the decreased renal and skeletal muscle mass and consequent decreased tissue binding of digoxin to Na + /K + -ATPase

Bedaquiline does not induce or inhibit major CYP isoenzymes, namely, CYP1A2, CYP2C9, CYP2C19, or CYP2D6 at clinically relevant concentrations, minimizing the risk of CYP450-related interactions (Mesens et al., 2010)