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[] Therefore, choline deficiency induced by dysbiosis will result in triglycerides (TG) accumulation in hepatocytes, secondary to lower hepatic secretion of VLDL

Further results from in vitro desuccinylation assays also demonstrated that HA-SIRT2 protein purified from HA-SIRT2 overexpressing HEK293T cells could efficiently desuccinylate GCLC in the presence of NAD + (Fig

Importantly, these are all features of ALD depending on the disease stage 5

When FTH1 is reduced, it causes intracellular iron overload, and iron overload promotes the production of large amounts of ROS by Fenton, consequently promoting cellular ferroptosis [142]