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Epilepsy Based on a placebo-controlled trial of adjunctive therapy for treatment of complex partial seizures, Depakote was generally well tolerated with most adverse reactions rated as mild to moderate in severity

Anastasiou D, Poulogiannis G, Asara JM, Boxer MB et al (2011) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

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Both NAD and B12 injections are administered as shots, so there may be a mild level of discomfort