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Principles of Fluid Mechanics for Large-Volume Delivery The effective SC delivery of large-volume biologics requires meticulous regulation of key fluid dynamics parameters, namely, flow rate, injection pressure, and delivery duration [48, 62]

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The amount of BG-ASO was constant for all transfections at 15 nM and conjugation-incompetent control ASO (20mer MOE) was spiked in to obtain the final ASO concentration to promote equal amounts of bound SNAP-BASU-His in all conditions