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Treatment recommendations depend on medical history, provider evaluation, laboratory findings, wellness goals, and clinical appropriateness

Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)

Frequency: 5x a week

Additionally, by engaging signaling pathways such as JAK/STAT, growth hormone may drive the transcription of genes involved in lipid mobilization, thereby further promoting lipolysis and potentially reducing visceral fat stores