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Glutathione deficiency may be caused by aging, by inadequate dietary intake of the sulfur-containing amino acid cysteine, or by exposure to damaging substances such as mycotoxins, drugs, alcohol and environmental pollutants

Am J Respir Crit Care Med 177(2):190194

Matsuzaki S, Pouly JL, Canis M (2023) IL-10 is not anti-fibrotic but pro-fibrotic in endometriosis: IL-10 treatment of endometriotic stromal cells in vitro promotes myofibroblast proliferation and collagen type I protein expression

Conventional drugs like metformin primarily exert their effects by improving IR, and studies have shown that they can modulate the gut microbiota, albeit with no significant impact on the levels of gut microbial metabolites ( in vitro fertilization demonstrated that berberine monotherapy was significantly superior to metformin monotherapy in improving live birth rate, reducing body mass index, decreasing follicle-stimulating hormone consumption, and enhancing gastrointestinal tolerability ( In the intervention of ferroptosis-related diseases, current therapeutic strategies face considerable challenges