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TB-500 and Thymosin Beta-4 are also prohibited by WADA/USADA under S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), applicable at all times both in-competition and out-of-competition TB-500 / Thymosin Beta-4 Clinical Trials: The RGN-352 and RGN-259 Programs RegeneRx Biopharmaceuticals has pursued two clinical development programs for Thymosin Beta-4, providing the most substantial human clinical data available for any TB-500-related compound: RGN-352 (Injectable Thymosin Beta-4 for Cardiac Repair): Phase 1 trial (completed): A double-blind, placebo-controlled study enrolled 40 healthy volunteers across four cohorts of 10 subjects each, testing escalating dose levels of intravenous Thymosin Beta-4 administered daily over 14 days

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In response to inflammatory mediators, ECs produce pro-inflammatory cytokines and chemokines such as IL-1, IL-6, CCL2, and CXCL1, and synthesize ICAM-1 and VCAM-1, facilitating the infiltration of immune cells [239]

Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency