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FASEB J 17(1):6769

This trauma extends beyond hair cells, impacting supporting cells essential for cochlear architecture and function, thereby jeopardizing the structural integrity of the auditory system

Following the above general procedure F, A and B respectively and starting from the commercially available 4-chloro-3-nitrobenzoic acid (Scheme 4), the crude reaction mixture was purified by column chromatography (dichloromethane:methanol=40:1) to provide the desired tert-butyl 3-amino-4-(2-adamantylamino)-benzoate (SRS16-82, Scheme 4) (700 mg, 2.046 mmol, 88% (3 steps)