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The significant quantitative metabolic alterations in Tbx1 +/ mice were provided by univariate analysis, as shown in the volcano plot (Fig 1A)

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We believe the stool-based tests are unique to other CRC screening tests in terms of their non-invasiveness, the fact that stool-based tests can be implemented by the patient at home and mailed into the lab, the absence of bowel preparation and anesthesia and the comparatively lighter burden and mitigated potential for over servicing of the patient and the healthcare system. We further wrote, [w]e agree that blood-based biomarker CRC screening tests have significant potential and we expanded coverage to include them in the reconsidered NCD 210.3, effective January 2021. We also recognized that blood-based biomarker CRC screening tests continue to be an emerging and quickly evolving technology