glutathione kidney disease Cystathionine γ-lyase deficiency exacerbates high-fat diet-induced and liver injury associated with disrupted homeostasis PDF) Restoring glutathione as therapeutic

Though the target seemed to have great promise, pramlintide was a commercial disappointment after its U.S

2013;8(10):e78715

The researchers found that elevated IS levels in CKD patients correlate with oxidative stress and neuroinflammation, contributing to the deterioration of glial cells

What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect