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Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study

These include: Endogenous reactive metabolites such as products arising from oxidative metabolism of lipids, nucleic acids and catecholamines Xenobiotics which are not normally found in the body and can include naturally occurring compounds or they can be man made in origin such as drugs or environmental pollutants Heavy metals such as mercury, lead, cadmium and arsenic The chemical reactivity of many of these compounds cause interference with the normal biological processes and hence they are toxic

Nat Prod Res 35:36673674