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The efferocytosis dilemma: how neutrophil extracellular traps and PI3K/Rac1 complicate diabetic wound healing

Iron overload enhances oxidative stress and the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome signaling, triggering the evolution of several inflammatory mediators, resulting in a cascade of inflammatory responses and renal dysfunction in iron-overloaded rats (Chaudhary et al., 2018)

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In addition, the mice also showed the phenotypes of increased mitochondrial oxidative stress, histopathological changes, and abnormal mitochondrial ultrastructure in cardiomyocytes