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Materials and methods Cell culture The human pancreatic cancer cell lines (CFPAC-1, SW1990, PANC-1, and BxPC-3) and murine pancreatic cancer cell line (Pan02) were procured from the Cell Bank of the Chinese Academy of Sciences Type Culture Collection (Shanghai, China)

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Finally, BOLD fMRI data were collected with an echo-planar imaging (EPI) sequence: TE = 30 ms, TR = 2500 ms, 90 degree flip angle, interleaved acquisition of 36 slices of 128 128 voxels (1.72 1.72 mm), 3.0 mm slice thickness with 0.5 mm gap (3.5 mm slice spacing)