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Glutathione Reductase (GR) The relationship between hydrogen water and glutathione reductase represents a fascinating interplay between exogenous antioxidant support and endogenous enzymatic systems

For instance GPx-1, which is the most abundant one in this family, is found mostly in the cytosol and in the matrix part of the mitochondria 11,13 , GPx-2 and GPx-3 are respectively observed in some types of endothelial cells and in the extracellular matrix 11,14 , GPx-4 mostly protects the biomembrane and the liposomes 11,15,16 and, has mitochondrial, cytosolic and nucleic forms and finally GPx-5 and GPx-6 are respectively expressed in the epididymis and the olfactory epithelium 11

Wu S, Liu X, Ren J, Qu X

These findings reinforce the conclusion that increased Se concentrations exacerbate oxidative stress, regardless of oxygen availability, although the effects are more pronounced under aerobic metabolism, in agreement with our first hypothesis