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Methotrexate, a dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide transformylase inhibitor, serves as the first-line treatment for RA due to its efficacy and accessibility

This effect may be attributed to decreased SN-38 exposure levels, as well as the anti-inflammatory and anti-apoptotic properties of SJW [105,106,107]

[7] Niacinamide Helps Reduce Sebum Production Despite being better known for its hydration and skin barrier benefits, niacinamide also regulates sebum (or oil) production which helps decrease the likeliness of clogged pores