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Several authors have described a negative correlation between CSF MHPG levels and cognitive functioning (Mann et al., 1983) and bradyphrenia (Mayeux et al., 1987) in PD patients, and others have described a relationship between CSF NE levels with severity of PD assessed by Hoehn & Yahr staging, akinesia scores, and freezing of the gait (Tohgi et al., 1993a)

However, the related clinical trials are limited in treating Alzheimers disease and HCV infection and have not acquired satisfactory results in prognosis, although the parameters of mitochondrial enzyme activities are improved to a certain extent

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An increasing body of evidence points to perturbed endosomal transport being a contributing factor and, in some cases, a causative factor in human diseases, including neurodegenerative and neurological 2,3,4 , and metabolic syndromes and cardiovascular disease 5