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The results of this study indicate that the salvage pathway for cysteine supply via GGCT helps to maintain GSH levels and serves as a resistance mechanism against therapeutic strategies that block cystine uptake via xCT inhibition

Ganguly, A., Pang, L., Duong, V

Furthermore, adopting specific methods to monitor ALT and other biomarkers is supposed to facilitate the prevention of DILI ( In addition, FDAs publication Drug-Induced Liver Injury: Premarketing Clinical Evaluation provides investigators with laboratory results of drugs that could be referred to predict severe DILI during the drug development process

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