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Adjunctive modafinil at initiation of treatment with a selective serotonin reuptake inhibitor enhances the degree and onset of therapeutic effects in patients with major depressive disorder and fatigue

Last reviewed: June 19, 2026 Last updated: June 19, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

We know, for example, that [15] small intestinal bacterial overgrowth (SIBO) is commonly found with Hashimotos (a 2007 study found that about 50 percent of people with hypothyroidism have this infection), and is associated with slow gut motility and intestinal permeability