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In chronic wounds, there is excessive secretion of inflammatory mediators, such as cytokines and matrix metalloproteinases (MMPs), which degrade growth factors and the extracellular matrix (ECM), further impairing healing

Ateahin A, Karahan I, Trk G, Gr S, Yilmaz S, Ceribai AO

Primary conclusions emphasized no significant average group differences in neurobehavioral outcomes, but secondary and re-analyses highlighted signals in subgroups, dose-response relationships, renal biomarkers, and genetic susceptibility.

The long-term clonal dynamics of lentivirally transduced hepatocytes remain incompletely characterized, and serial transplantation studies in animal models have demonstrated that specific integration sites can confer subtle proliferative advantages, leading to progressive clonal dominance over months to years [256]