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10.18632/aging.100189 77 WangB.HanJ.ElisseeffJ

22b.2.5 Urinary methylmalonic acid excretion Vitamin B12 serves as a cofactor for methylmalonyl CoA mutase (EC 5.4.99.2) as noted earlier.This enzyme acts in the conversion of methylmalonyl CoA to succinyl CoA (Figure 22b.7)

As Frontiers in Endocrinology (2023) confirmed: "Most known selenoproteins, such as glutathione peroxidase, are expressed in the thyroid and are involved in thyroid hormone metabolism, redox state regulation, and maintenance of cellular homeostasis." In other words, selenium's documented benefits for Hashimoto's thyroiditis are mechanistically dependent on adequate glutathione availability