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Key Points Growth hormone (GH) is a potent metabolic hormone that has been touted as a 'fountain of youth' Recombinant human (rh) GH and insulin-like growth factor 1 (IGF-1) are approved therapeutics for patients with GH deficiency or primary IGF-1 deficiency, respectively

Their findings revealed a significant reduction in glucose production and expression of both G6pc and Pck1 in hepatocytes with NNMT overexpression and concurrent Sirt1 inhibition, compared to hepatocytes with NNMT overexpression alone

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Several scientific evidences suggest that different extraction methods can yield varied phytochemical constituents of the evaluated plant extract and plays critical role in determining its biological potential