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doi: 10.15850/amj.v3n3.474 15 SmolenJSLandewRBMBijlsmaJWJBurmesterGRDougadosMKerschbaumerAet al

Reports indicate that targeting EZH2 can modulate the H3K27me3 level of HMGA2 to inhibit PI3K/Akt phosphorylation, thereby suppressing cancer cell proliferation and reducing the resistance of CRC to oxaliplatin

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