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The hypothalamus governs the timing of those pulses through two opposing signals: GHRH (growth-hormone-releasing hormone), which stimulates release, and somatostatin , which inhibits it

These findings reinforce the value of immune-centric systems biology frameworks for understanding disease heterogeneity and informing future immune-oriented stratification and therapeutic exploration

These differences profoundly influence mycotoxin absorption, distribution, metabolism, excretion, and toxicity, as well as microbiota composition and responses to dysbiosis (18)

The assessment of additional epigenetic and biochemical markers could also provide deeper insights into the observed differences between groups, ultimately contributing to the development of more effective and personalized intervention strategies