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The dual-agonist design was first characterized by Coskun and colleagues, who showed that a single peptide could engage both receptors with carefully tuned affinities (Coskun et al., Molecular Metabolism 2018

It is used to prevent and to treat vitamin B12 deficiency

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Less than the normal dietary intake of B12 can increase the incidence of palpitations (perceived sensation of increased or irregular heart beating), which makes you feel your heart beating in your chest, seemingly speeding up or running at an irregular rhythm