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In parallel, butyrate also functions as a histone deacetylase (HDAC) inhibitor, influencing epigenetic gene expression ( reg ) differentiation, induce antimicrobial peptide expression (e.g., -defensins, RegIII), and maintain epithelial barrier integrity (Isobe et al., 2020

Clinical reports note that patients often experience rapid improvements in headache, dizziness, weakness, and fatigue within minutes to an hour after IV rehydration