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Some comparative evaluation of adverse events including hepatotoxicity, related to antithyroid drugs has been done previously.29,77,78 In these investigations, the authors tried to find a relationship between the age of patients and the development of hepatotoxicity induced by methimazole and/or PTU

Impairments in the ability to generate ATP from canonical mitochondrial pathways, such as the TCA or electron transport chain, drive additional neurophysiological impairments even after primary injury and initial ischemia resolve

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