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NL-GHK-Cu Peptide Therapy: During conducted studies, it was shown that therapy with the NL-GHK-Cu peptide reduced the production of reactive oxygen species (ROS) and increased superoxide dismutase (SOD) activity while simultaneously decreasing the production of TNF- and IL-6 by suppressing NF-B p65 and p38 MAPK signaling, whereby the peptide weakened histological changes in the lungs caused by damage and suppressed the infiltration of inflammatory cells into the lung parenchyma, resulting in alleviation of lung injury and elimination of ongoing inflammation

In vitro and in vivo studies indicate that the vitamin D signalling pathway is essential for epithelial barrier function through increasing the expression of tight junction proteins (139)

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