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Biological and molecular profile of fracture non-union tissue: current insights

-Aminoisobutyric acid, a natural non-protein -amino acid, activates the LKB1/AMPK/SIRT1 axis, promotes NF-B p65 phosphorylation and nuclear translocation, delays IB phosphorylation and degradation, alleviates VSMC inflammation, and activates Nrf2 to relieve oxidative stress, collectively inhibiting VSMC proliferation and migration [221]