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Saikosaponin D inhibits proliferation and promotes apoptosis through activation of MKK4-JNK signaling pathway in pancreatic cancer cells

Biochim Biophys Acta 710(2):197211 Ng SC, Zeng Z, Niewiadomski O, Tang W, Bell S, Kamm MA, Hu P, De Silva HJ, Niriella MA, Udara WY, Ong D, Ling KL, Ooi CJ, Hilmi I, Lee Goh K, Ouyang Q, Wang YF, Wu K, Wang X, Pisespongsa P, Manatsathit S, Aniwan S, Limsrivilai J, Gunawan J, Simadibrata M, Abdullah M, Tsang SWC, Lo FH, Hui AJ, Chow CM, Yu HH, Li MF, Ng KK, Ching JYL, Chan V, Wu JCY, Chan FKL, Chen M, Sung JJY (2016) Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia

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In the acidic stomach and hypoxic tissues, nitrite is further reduced to NO, a vasodilator that improves endothelial function and lowers BP