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Furthermore, by using a luciferase reporter system with a UGA codon inserted in the protein coding region of the luciferase reporter gene, we confirmed that selenium-dependent expression was independent of the GPx1 promoter [68]

However, this does not typically result in their death due to the capacity of Glu to synthesize glutathione (GSH), a vital antioxidant that plays a crucial role in cancer cells and their resistance to oxidative stress [45]