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Pre-treatment with AG490 reduced both astrocytic and microglial densities (GFAP and Iba-1 markers, respectively), as well as decreased inducible nitric oxide synthase (iNOS), whose increased production is observed in pro-inflammatory reactive microglia [104], and S100-beta, an astrocytic marker that is upregulated in PD models [97, 105]

Unlike OCPs, which suppress the hypothalamicpituitaryovarian (HPO) axis pharmacologically, apigenin and ellagic acid modulate endocrine function physiologically, suggesting potential for safer long-term reproductive outcomes (82, 86)

Published in Pharmaceuticals by Sikiric and colleagues, the comprehensive review synthesizes decades of preclinical research demonstrating BPC-157s remarkable ability to modulate dopaminergic, serotonergic, glutamatergic, GABAergic, and nitric oxide systems simultaneously