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3) prediction of GDAP1 structure from AlphaFold suggest the -loop may adopt a two helical bundle with hinges that allow it to fold over the G- and H-sites, making a direct contact with the G-site and forming a lid that completes the canonical binding pocket (Jumper and Hassabis, 2022), and 4) the -loop domain contains a number of CMT causing mutations that are found either within the helical bundle but also near the hinge regions

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Shergalis, A

It is not an approved drug, food, or dietary supplement and is not intended for human or animal consumption