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Pharmacotherapy 2006

Kang SJ, Lee YJ, Lee EK, Kwak MK (2012) Silver nanoparticles-mediated G2/M cycle arrest of renal epithelial cells is associated with NRF2-GSH signaling

In addition, CTLA-4 is able to bind to CD80 and CD86, which are both expressed on the surface of tumor cells and APCs

Thus, while the estimation of the amount of a loading dose may be quite correct, the rate of administration can sometimes be crucial in preventing excessive drug concentrations, and slow administration of an intravenous drug (over minutes rather than seconds) is almost always prudent practice