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Introduction Over the past two decades, numerous studies have revealed the physiological and metabolic effects of the microbiome on multicellular organisms, with implications for both health and disease

In vitro experiments have shown that selenium reduces the activity of hydroxylases that activate carcinogens, such as aryl hydroxylase (AHH), by more than 50% and weakens the metabolism of PAH compounds into carcinogens

The combination of CB-839 and azacytidine (AZA) was found to be synergistic in a single-arm, open-label, phase 1b/2 study conducted in patients diagnosed with advanced myelodysplastic syndromes (MDS)