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Clinical outcomes associated with drugs for obesity and overweight: A systematic review and network meta-analysis of randomized controlled trials

Methylation Reactions Methionine S-Adenosyl-Methionine (SAMe) SAMe serves as the bodys universal methyl donor , involved in: Epigenetic DNA methylation Neurotransmitter synthesis (dopamine, serotonin, norepinephrine) Phospholipid and myelin production Detoxification pathways C

Oral Medication Preference# Recommendation : Semaglutide Reason : Rybelsus (oral semaglutide) is available for patients preferring pills

The ethical principles of the study are in accordance with the European Directive 010/63/E, the Act on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the Ordinance on the Protection of Animals Used for Scientific Purposes (Official Gazette 55/13), the recommendations of the Federation of European Laboratory Associations for Animal Science (FELASA), and the recommendations of the Ethics Committee of the Faculty of Medicine, University of Zagreb