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These results indicated that RS could respond to intracellular GSH and transform into fibrous nanostructure in high GSH level B16 cells, which is consistent with the results of LCMS traces (Fig

This is further complicated by the fact that different types of grapes and growing seasons result in inconsistent amounts of these beneficial compounds

Using mouse kidney cells, which are known to have GSH transporters, as a model, it was further demonstrated that COXP DiR micelles entered the cells in an energy dependent mechanism and the penetration was inhibited by probenecid consistent with a GSH transporter-mediated process [52]