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52 This proof-of-concept study in a cadaveric porcine model found reduced CaHA microspheres upon histopathologic evaluation 24 hours after treatment

Yes common grades include USP, EP, and JP

doi:10.1186/s13075-022-02859-x 165

Kevin Yarasheski at The Washington University School of Medicine had to stop his 1993 trial on twelve subjects aged from 63 to 76 when half of them developed carpal tunnel compression, fluid retention and symptoms of arthritis within weeks of initiating treatment