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Quantitative measurements confirmed these observations, with FOXO4-DRI treatment significantly increasing voluntary running wheel activity in aged mice

This is likely because sermorelin cannot result in an excessively high rise in serum GH or IGF-1 concentrations, in contrast to GH therapy [29]

SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials

Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1