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Author contributions MX: Writingoriginal draft

Human Data Congenital Malformations The North American Antiepileptic Drug Pregnancy Registry reported 16 cases of congenital malformations among the offspring of 149 women with epilepsy who were exposed to valproic acid monotherapy during the first trimester of pregnancy at doses of approximately 1,000 mg per day, for a prevalence rate of 10.7% (95% CI 6.3%-16.9%)

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The most notable sources include: Watermelon : Contains the highest natural concentration of L-citrulline Cucumbers : Provide moderate levels of this amino acid Pumpkins and Squashes : Offer smaller but notable amounts of L-citrulline Bitter melons : Another vegetable source known for its L-citrulline content Physiological Role of L-Citrulline L-citrulline supports several important functions in the body, such as: Nitric Oxide Production : L-citrulline converts to L-arginine in the kidneys, which then supports the bodys nitric oxide production