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Light or heavy stable isotope-labelled iodoacetamide (IAM) is used to differentially modify free reduced cysteine thiols between two samples, and the ratio between heavy and light IAM-labelled cysteine containing peptides is used to compare the levels of reduced cysteine residues between samples

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In this regard, the designation of HNPCC also encompasses cases of familial CRC that are MSI and exhibit features of LS but lack germline mutations involving mismatch repair genes (Lynch-like syndromes) or appear to be familial but are MSS and lack germline mutations (familial colorectal cancer type X) [24, 26,27,28,29,30]

A qualitative value was given to each antioxidant therapy according to its effect on every symptom (improved, not improved or no information), data was visually reported using ChatGPT 4.0 and Google Collab