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Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism

8 Streptozotocin (STZ), a glucose analog derived from Streptomyces achromogenes , selectively targets and destroys pancreatic beta cells in rodent models, serving as a widely utilized tool for inducing experimental diabetes

Moreover, hemideficiency of the SLC25A1 or SLC25A4 orthologues in Drosophila appeared to be associated with abnormal synapse morphology, and deficits in synaptic plasticity and neurotransmission [359]

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